ACP Broadsheet No 149: September 1996. Serological diagnosis of gluten sensitive enteropathy.

ACP Broadsheet no 125: July 1990. Bacteriological diagnosis of diphtheria.

Gluten-sensitive enteropathy: Synthesis

The intestinal mucosa of patients with gluten-sensitive enteropathy responds to gluten challenge in vivo with a striking increase in IgA and IgM synthesis. Whether this increase in immunoglobulin synthesis is due in some part to the production of antigliadin antibodies is examined. Using an affinity chromatography technique it has been demonstrated that in six of seven patients with gluten-sens...

ACP Broadsheet No 141: September 1993. Role of endocrine biochemistry laboratories in the investigation of infertility.

The staff and services of the endocrine biochemistry laboratory are essential to the efficient investigation of infertility. Each centre should adopt a detailed strategy for the investigation of the infertile couple which specifies the hormone analyses required at each stage. Appropriate first-line hormone tests should be selected after a thorough clinical history and physical examination of bo...

ACP Broadsheet No 150. March 1997. Antenatal serological testing and prevention of haemolytic disease of the newborn.

Introduction Routine antenatal serological screening has been practised throughout the United Kingdom and worldwide for about 30 years.' Originally introduced to detect pregnancies at risk of haemolytic disease of the newborn (HDN) due to Rh anti-D antibodies, its continued use has led to an increasing realisation of the clinical importance of other red cell antibodies in the pathogenesis of HD...

Prevalence of hyperhomocysteinemia in adult gluten-sensitive enteropathy at diagnosis: role of B12, folate, and genetics.

BACKGROUND & AIMS Hyperhomocysteinemia, a risk factor for thrombosis, recurrent miscarriages, and osteoporosis, might derive from acquired folate and vitamin B 12 deficiencies and from a C677T mutation in methylene-tetrahydrofolate reductase (MTHFR) gene. Undiagnosed gluten-sensitive enteropathy (GSE) is associated with vitamin deficiencies, osteoporosis, and recurrent miscarriages. We evaluate...